EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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Palestinian death toll in Gaza reaches 100: Health Ministry

GAZA (Reuters) - The number of Palestinians killed in Gaza during Israel's on-going offensive reached 100 on Monday, the Hamas-run Health Ministry said.

On his Facebook page, ministry spokesman Ashraf Al-Qidra listed Mohammed Tbail, killed in an air strike in Nusseirat refugee camp, as the 100th Palestinian fatality.

Qidra said the Palestinian dead included 24 children and 10 women. Ministry figures for the number of men killed in the conflict with Israel make no distinction between civilians and militants.

According to the ministry, 850 people have been wounded in Gaza since the hostilities began on Wednesday. They included 260 children and 140 women.

Israel puts its death toll since Wednesday at three civilians - two men and a woman killed by a rocket fired from Gaza. Police said more than 60 people have been wounded.

(Reporting by Nidal al-Mughrabi, Writing by Jeffrey Heller in Jerusalem, Editing by Allyn Fisher-Ilan)

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Obama: Historic Myanmar visit is sign of progress

BANGKOK (AP) — On the eve of his landmark trip to Myanmar, President Barack Obama tried to assure critics that his visit was not a premature reward for a long-isolated nation still easing its way toward democracy.

"This is not an endorsement of the government," Obama said Sunday in Thailand as he opened a three-county dash through Asia. "This is an acknowledgement that there is a process under way inside that country that even a year and a half, two years ago, nobody foresaw."

Obama was set to become the first U.S. president to visit Myanmar with Air Force One scheduled to touch down in Yangon on Monday morning. Though Obama planned to spend just six hours in the country, the much-anticipated stop came as the result of a remarkable turnaround in the countries' relationship.

The president's Asia tour also marks his formal return to the world stage after months mired in a bruising re-election campaign. For his first postelection trip, he tellingly settled on Asia, a region he has deemed the region as crucial to U.S. prosperity and security.

Aides say Asia will factor heavily in Obama's second term as the U.S. seeks to expand its influence in an attempt to counter China.

China's rise is also at play in Myanmar, which long has aligned itself with Beijing. But some in Myanmar fear that China is taking advantage of its wealth of natural resources, so the country is looking for other partners to help build its nascent economy.

Obama has rewarded Myanmar's rapid adoption of democratic reforms by lifting some economic penalties. The president has appointed a permanent ambassador to the country, also known as Burma, and pledged greater investment if Myanmar continues to progress following a half-century of military rule.

But some human rights groups say Myanmar's government, which continues to hold hundreds of political prisoners and is struggling to contain ethnic violence, hasn't done enough to earn a personal visit from Obama.

Speaking from neighboring Thailand, Obama said Sunday he was under no illusions that Myanmar had done all it needed to do. But he said the U.S. could play a critical role in helping ensure the country doesn't slip backward.

"I'm not somebody who thinks that the United States should stand on the sidelines and not want to get its hands dirty when there's an opportunity for us to encourage the better impulses inside a country," Obama said during a news conference with Thailand's prime minister, Yingluck Shinawatra.

Even as Obama turned his sights on Asia, widening violence in the Middle East competed for his attention.

Obama said Israel had the right to defend itself against Hamas' missile attacks from Gaza. But he urged Israel not to launch a ground assault in Gaza, saying it would put Israeli soldiers, as well as Palestinian citizens, at greater risk and hamper an already vexing peace process.

"If we see a further escalation of the situation in Gaza, the likelihood of us getting back on any kind of peace track that leads to a two-state solution is going to be pushed off way into the future," Obama said.

The renewed instability in the Mideast is likely to trail Obama as he makes his way from Thailand to Myanmar and then Cambodia, his final stop before returning to Washington early Wednesday.

Obama planned talks in Myanmar with Prime Minister Thein Sein, who has orchestrated much of his country's recent reforms, and was expected to meet with democracy activist Aung Sun Suu Kyi in the home where she spent years under house arrest.

The president has trumpeted Suu Kyi's support of his outreach efforts, saying she was "very encouraging" of his trip.

The White House said Obama intended to express concern about ethnic tensions in Myanmar's western Rakhine state, where more than 110,000 people, the vast majority of them Muslims known as Rohingya, have been displaced.

The U.N. has said the Rohingya. who are widely reviled by the Buddhist majority in Myanmar, are among the world's most persecuted people.

The White House said Obama planned to press the matter with Thein Sein, along with demands to free remaining political prisoners.

The president also prepared to give a speech at Rangoon University, the center of the country's struggle for independence against Britain and the launching point for many pro-democracy protests. The former military junta shut the dormitories in the 1990s fearing further unrest and forced most students to attend classes on satellite campuses on the outskirts of town.

Obama began his Asian tour on a steamy day in Bangkok with a visit to the Wat Pho Royal Monastery. In stocking feet, the president and Secretary of State Hillary Rodham Clinton walked around a golden statue of a sitting Buddha. The complex is a sprawling display of buildings with colorful spires, gardens and waterfalls.

Obama then paid a courtesy call to the ailing, 84-year-old U.S.-born King Bhumibol Adulyadej in his hospital quarters. The king, the longest serving living monarch, was born in Cambridge, Mass., and studied in Europe.

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Associated Press writer Jim Kuhnhenn contributed to this report.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Afghanistan says Pakistan will help in peace talks

KABUL, Afghanistan (AP) — A top Afghan peace mediator hailed Pakistan's recent decision to free nine members of the Taliban who favor negotiations, saying Saturday it was a sign Islamabad is willing to help bring the militant group to the table and end Afghanistan's 11-year-old war.

The cooperation of Pakistan, which has longstanding ties to the Taliban, is seen as key to jumpstarting the stalled Afghan peace process. The Afghan and U.S. governments accuse Islamabad of backing insurgents — an allegation Pakistan denies — and say many militant leaders are hiding in the country.

Afghanistan needs Pakistan's help in reaching out to top Taliban leaders, but still insists that peace talks be led by Afghans, saying it will fight those who try to interfere.

Salahuddin Rabbani, the head of the High Peace Council who led a delegation to Islamabad this week, said Pakistan's prisoner release marked a shift in the neighboring country's policy. In the past, the Pakistanis have arrested Taliban figures interested in peace talks with the Afghan government, he said, but now the government is releasing them and pledging to give them safe passage to negotiations.

"It seems that Pakistani officials have realized that a close cooperation between Afghanistan and Pakistan can be effective for the peace initiative," Rabbani said. "Of course, this is a vision we have been insisting on for a long time."

Rabbani, whose delegation spent four days in Islamabad this week meeting with high-ranking government, political and religious leaders, said Pakistan has pledged to release additional Taliban prisoners who will be allowed to stay in Pakistan, return to Afghanistan or seek residence in a third country. While nothing can guarantee they won't rejoin Taliban fighters, Rabbani said he was confident that they would continue to cooperate with the peace council. "We will be in contact with those released," he said.

Some members of the peace council suggested that Pakistan's religious and political leadership might be having a change of heart — in part because of violence committed by Pakistan's branch of the Taliban movement.

"This is the first time that we really saw some changing of the minds while we were speaking," said Qayumuddin Kashaf, a member of peace council and head of the top religious council in Afghanistan. He said that in the past, Pakistani religious leaders insisted that insurgents were waging a holy war in Afghanistan. "Now we see some changing of the mindset because the security situation in Pakistan is very bad if not worse than Afghanistan."

Others in Kabul believe, however, that Pakistan may simply be playing a waiting game, trying to appease Afghanistan with small gestures until international troops leave Afghanistan and the Taliban can try to mount a comeback.

Despite the prisoner release, the peace process still has little traction and has experienced many setbacks, including the assassination of Rabbani's father in September 2011. Burhanuddin Rabbani, a former Afghan president and the first leader of the peace council, was killed in his Kabul home by a suicide bomber posing as an emissary from the Taliban.

It's unclear whether the Taliban are interested in negotiating peace, but the insurgent group welcomed the release of the prisoners. "Without a doubt, releasing prisoners fosters confidence between two neighboring countries and their nations," Taliban spokesman Zabihullah Mujahid said in a statement issued Friday.

During the delegation's trip, both countries appealed to the Taliban to join the peace process and sever ties with al-Qaida and other international terror networks. They said Pakistan, Afghanistan and the United States would provide safe passage to members of the Taliban who want to talk with negotiators.

They agreed to work with the international community to remove prospective Taliban negotiators from the U.N. sanctions list so they can participate in any peace talks. The sanctions include a travel ban, arms embargo and assets freeze.

Afghanistan and Pakistan also agreed to hold a conference of religious leaders and scholars from Islamic countries to address violence in the name of Islam, council members said.

The peace council did not identify the prisoners who were freed, but an Afghan official familiar with the peace process gave The Associated Press a list of eight. They were:

—Nooruddin Turabi, former Taliban justice minister.

—Jahangirwal, a special assistant to Taliban leader, Mullah Omar.

—Qutub, a Taliban leader.

—Abdul Salaam, former Taliban governor of Baghlan province.

—Maulvi Matiullah, the Taliban's director of the customs house in Kabul.

—Mahamad, the Taliban's former governor of Kunduz province.

—Sayed Saduddin Agha, a former Taliban commander.

—Allah Dad, the Taliban's former deputy minister of communication.

The ninth prisoner released was Anwarul Haq Mujahid, the son of the late Mohammad Yunus Khalis, who fought against the Soviets in Afghanistan in the 1980s. He has joined his family in the northwestern Pakistani city of Peshawar, according to a cousin and family friend who spoke on condition of anonymity because they were not authorized to talk to the media.

Afghan officials are still hoping for the release of the Taliban's former deputy leader, Mullah Abdul Ghani Baradar, who was captured in Pakistan in 2010. Baradar was reportedly conducting talks with the Afghan government that were kept secret from the Pakistanis.

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Lady Gaga tweets some racy images before concert

BUENOS AIRES, Argentina (AP) — Lady Gaga's tweets were getting a lot of attention ahead of her Buenos Aires concert Friday night.

The Grammy-winning entertainer has more than 30 million followers on Twitter and that's where she shared a link this week to a short video showing her doing a striptease and fooling around in a bathtub with two other women.

She told her followers that it's a "surprise for you, almost ready for you to TASTE."

Then, in between concerts in Brazil and Argentina, she posted a picture Thursday on her Twitter page showing her wallowing in her underwear and impossibly high heels on top of the remains of what appears to be a strawberry shortcake.

"The real CAKE isn't HAVING what you want, it's DOING what you want," she tweeted.

Lady Gaga wore decidedly unglamorous baggy jeans and a blouse outside her Buenos Aires hotel Thursday as three burly bodyguards kept her fans at bay. Another pre-concert media event where she was supposed to be given "guest of honor" status by the city government Friday afternoon was cancelled.

After Argentina, she is scheduled to perform in Santiago, Chile; Lima, Peru; and Asuncion, Paraguay, before taking her "Born This Way Ball" tour to Africa, Europe and North America.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Israel hits Hamas government buildings, reservists mobilized

GAZA/JERUSALEM (Reuters) - Israeli aircraft bombed Hamas government buildings in Gaza on Saturday, including the prime minister's office, after Israel's cabinet authorized the mobilization of up to 75,000 reservists in preparation for a possible ground invasion.

Palestinian militants in Gaza kept up cross-border salvoes, firing a rocket at Israel's biggest city Tel Aviv for the third straight day. Police said it was destroyed in mid-air by an Iron Dome anti-missile battery deployed hours earlier, and no one was injured.

Hamas, the Palestinian Islamist group that runs the Gaza Strip, said Israeli missiles wrecked the office building of Prime Minister Ismail Haniyeh - where he had met on Friday with the Egyptian prime minister - and struck a police headquarters.

In the Israeli Mediterranean port of Ashdod, a rocket ripped into several balconies. Police said five people were hurt.

With Israeli tanks and artillery positioned along the Gaza border and no end in sight to hostilities now in their fourth day, Tunisia's foreign minister travelled to the enclave in a show of Arab solidarity.

Officials in Gaza said 41 Palestinians, nearly half of them civilians including eight children and a pregnant woman, had been killed since Israel began its air strikes. Three Israeli civilians were killed by a rocket on Thursday.

In Cairo, a presidential source said Egyptian President Mohamed Mursi would hold four-way talks with the Qatari emir, the prime minister of Turkey and Hamas chief Khaled Meshaal in the Egyptian capital on Saturday to discuss the Gaza crisis.

Egypt has been working to reinstate calm between Israel and Hamas after an informal ceasefire brokered by Cairo unraveled over the past few weeks. Meshaal, who lives in exile, has already held a round of talks with Egyptian security officials.

Israel uncorked its massive air campaign on Wednesday with the declared goal of deterring Hamas from launching rockets that have plagued its southern communities for years. The salvoes recently intensified, and are now displaying greater range.

The operation has drawn Western support for what U.S. and European leaders have called Israel's right to self-defense, along with appeals to both sides to avoid civilian casualties.

Hamas, shunned by the West over its refusal to recognize Israel, says its cross-border attacks have come in response to Israeli strikes against Palestinian fighters in Gaza.

"We have not limited ourselves in means or in time," Israeli Foreign Minister Avigdor Lieberman said on Israel's Channel One television. "We hope that it will end as soon as possible, but that will be only after all the objectives have been achieved."

Hamas says it is committed to continued confrontation with Israel and is eager not to seem any less resolute than smaller, more radical groups that have emerged in Gaza in recent years.

The Islamist movement has ruled Gaza since 2007. Israel pulled settlers out of Gaza in 2005 but maintains a blockade of the tiny, densely populated coastal territory.

RESERVE TROOP QUOTA DOUBLED

At a late night session on Friday, Israel's cabinet decided to more than double the current reserve troop quota set for the Gaza offensive to 75,000, political sources said.

The move did not necessarily mean all would be called up or that an invasion would follow. Tanks and self-propelled guns were seen near the sandy border zone on Saturday, and around 16,000 reservists have already been summoned to active duty.

The Gaza conflagration has stirred the pot of a Middle East already boiling from two years of Arab revolution and a civil war in Syria that threatens to spread beyond its borders.

U.N. Secretary-General Ban Ki-moon is expected to visit Israel and Egypt next week to push for an end to the fighting in Gaza, U.N. diplomats said on Friday.

Hamas's armed wing claimed responsibility for Saturday's rocket attack on Tel Aviv, saying it had fired a longer-range, Iranian-designed Fajr-5 at the coastal metropolis, some 70 km (43 miles) north of the Gaza Strip.

After air raid sirens sounded, witnesses saw two white plumes rise into the sky over the southern outskirts of Tel Aviv and heard an explosion when the incoming rocket was hit.

The anti-missile battery had been due to take delivery of its fifth Iron Dome battery early next year but it was rushed into service near Tel Aviv after rockets were launched toward the city on Thursday and Friday. Those attacks caused no damage or casualties.

In Jerusalem, targeted by a Palestinian rocket on Friday for the first time in 42 years, there was little outward sign on the Jewish Sabbath that the attack had any impact on the usually placid pace of life in the holy city.

In Gaza, some families abandoned their homes - some of them damaged and others situated near potential Israeli targets - and packed into the houses of friends and relatives.

ISRAEL'S GAZA TARGETS

The Israeli army said it had zeroed in on a number of government buildings during the night, including Haniyeh's office, the Hamas Interior Ministry and a police compound.

Taher al-Nono, a spokesman for the Hamas government, held a news conference near the rubble of the prime minister's office and pledged: "We will declare victory from here."

A three-storey house belonging to Hamas official Abu Hassan Salah was also hit and totally destroyed early on Saturday. Rescuers said at least 30 people were pulled from the rubble.

In Washington, U.S. President Barack Obama commended Egypt's efforts to help defuse the Gaza violence in a call to Mursi on Friday, the White House said in a statement, and underscored his hope of restoring stability there.

On Friday, Egyptian Prime Minister Hisham Kandil paid a high-profile visit to Gaza, denouncing what he called Israeli aggression and saying Cairo was prepared to mediate a truce.

Egypt's Islamist government, freely elected after U.S.-backed autocrat Hosni Mubarak fell to a popular uprising last year, is allied with Hamas but Cairo is also party to a 1979 peace treaty with Israel.

In a call to Netanyahu, Obama discussed options for "de-escalating" the situation, the White House said, adding that the president "reiterated U.S. support for Israel's right to defend itself, and expressed regret over the loss of Israeli and Palestinian civilian lives".

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-09, killed over 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

But few believe Israeli military action can snuff out militant rocket fire entirely without a reoccupation of Gaza, an option all but ruled out because it would risk major casualties and an international outcry.

While Hamas rejects the Jewish state's existence, Palestinian President Mahmoud Abbas, who rules in areas of the nearby West Bank not occupied by Israelis, does recognize Israel but peace talks between the two sides have been frozen since 2010.

(Additional reporting by Maayan Lubell, Jeffrey Heller and Ori Lewis in Jerusalem and Louis Charbonneau at the United Nations; Writing by Jeffrey Heller; Editing by Mark Heinrich)

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Jason Mraz to make historic appearance in Myanmar

NASHVILLE, Tenn. (AP) — Jason Mraz will make history next month when he performs in Myanmar to raise awareness about human trafficking.

Mraz will headline a free outdoor concert on Dec. 16 at People's Square in Yangon, at the base of Shwedagon Pagoda.

The Grammy-winning singer-songwriter is believed to be the first international artist to perform an open-air concert in the country. The show includes local acts and is hosted by MTV EXIT, the music channel's initiative to raise awareness about human trafficking and exploitation.

"That's pretty exciting," Mraz said of the history involved, "and I'm going there with an enormous amount of gratitude and respect, and I hope we can actually make a difference. I hope it's also a testament to the songs. I've always wanted my songs to be about healing and self-empowerment, and if this is the way MTV is acknowledging that, then I am incredibly grateful."

The show, which will include local acts, will be broadcast on Myanmar national television and will air on MTV's international network in 2013. Mraz hosted a similar concert in the Philippines last year. He first became interested in the issue about four years ago when he attended the Freedom Awards, an annual salute to those working against human exploitation put on by the organization Free the Slaves.

"I thought this was something that was abolished when Abraham Lincoln signed the Emancipation Proclamation, but all it did is become hidden from our view," Mraz said in a phone interview from Zurich, Switzerland. "There was a recent estimate that there are about 27 million people enslaved on the planet, certainly due to hard economic times not just in the Western world but certainly in Third World countries. Humans as a commodity is a great way to run your business. So I signed on, lent my voice, lent my music to the cause."

Myanmar is opening itself to the world since a military junta ceded power to a new elected government last year. President Thein Sein's government has pushed the country toward democracy, and this Monday Barack Obama is scheduled to become the first sitting U.S. president to visit the country.

Mraz says there is concern predators will prey on the vulnerable in this time of great flux. The concert offers an opportunity to "educate, empower and engage." The 35-year-old singer says he plans to tailor his show to the message.

"I do curate a set list that I feel is going to be part of that educate, empower and engage (theme)," he said. "Obviously songs like 'I'm Yours,' 'I Won't Give Up' are great examples. Or '93 Million Miles' is a new one where it's about believing in yourself. And a lot of my songs are about that, about believing in yourself and really going for your dreams. Those are the kinds of songs I'll be playing at that show."

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MTV is a unit of Viacom Inc.

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Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott .

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..